If it's going to be timber with 100mm PIR, have you considered SIPs? The build will be much faster and you'll get less coldbriding from studs and screws interrupting the insulation.
SIP construction isn't something I'd really considered, to be honest.
The difference in u-value between a SIP wall versus timber & PIR wall seems to be negligible or worse, depending on which manufacturer site you look at.
Moving big SIP boards would be a challenge too, given the access I have.
If it's going to be timber with 100mm PIR, have you considered SIPs? The build will be much faster and you'll get less coldbriding from studs and screws interrupting the insulation.