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I rode that from Shoreditch to Canary Wharf for a couple of years. Peds not a problem but expect punctures, dogs running under your wheels and occasionally passing kids that push you in and nick your bike. (The last one didn't happen to me but saw the aftermath).
Still beat the roads though, was a nice way to see the seasons.
Regent's Canal: what do people think, if you use it for a short bit rather than the roads? Cycling steady and keeping a careful watch on everyone else, and has a bike that makes enough noise by itself; or blasting along, dinging your bell at everyone and than blaring 'ring your bell when you pass someone' as you go by?