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For me it would all depend on the setup. If you have another bog on the 1st floor (or whatever floor the bedroom is on) then its a bit unusual but nothing major. If on the other hand you only have a downstairs lav and find yourself getting up in the night to schlep downstairs then it would get old quickly.
If it's a question of space then I would expect it would be self explanatory when you come to sell on. Also I'm personally not a fan of overly cramped bathrooms.
Are you sure that a macerator is your only option for running waste?
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A bit weird. I'd say a toilet in there that's rarely used would still be a better option.
I have a toilet (in a loft conversion) which isn't on an external wall. The waste pipe runs under the floor with enough of a drop to not require it. It means that a small section of pipe had to be boxed in to get sufficient drop but it isn't noticeable.
Yes unfortunately. I have one in my flat.