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That's what I found too re: cranks.
I've raced with 40T and 42T using an R8000 Ultegra RD (the newer shadow mount one). Works fine. I think the 46T might need a WolfTooth Roadlink but I don't own one to test it out.
42T got me around Transiberica with no recurrence of the knee troubles that plagued my last TCR. I was just thinking on gravel lower would be better.
hippy-
ah you want to try the 11/46 cassette. If you have a 12 tooth difference on the front like a 46/34, then I think you can push the 1x GRX rear mech to do 46 with the mod I mentioned on page 1 of this thread. The point of the long cage XT mod is to take up the chain slack. The body of that GRX should handle the jump to 46.
Bob_Thod
As per my last research and testing extravaganza, there were no solutions for a 5x110 BCD that went lower than a 33 tooth. And I think that 33 came from one of the French chain ring manufacturers, TA Specialities maybe? It is not possible to go smaller than 33 with a 5x110. Praxis works did something that went down to 32, but that is only with their cranks.
46 tooth 5x110 rings are often paired with a 36 or 39 tooth inner ring (for cx). All the ones I've tried work fine with a 34 inner.
How did your experiment with the 11/40 cassette go? Is it enough or you looking for more?