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That's what I found too re: cranks.
I've raced with 40T and 42T using an R8000 Ultegra RD (the newer shadow mount one). Works fine. I think the 46T might need a WolfTooth Roadlink but I don't own one to test it out.
42T got me around Transiberica with no recurrence of the knee troubles that plagued my last TCR. I was just thinking on gravel lower would be better.
hippy
@Bob_Thod
As per my last research and testing extravaganza, there were no solutions for a 5x110 BCD that went lower than a 33 tooth. And I think that 33 came from one of the French chain ring manufacturers, TA Specialities maybe? It is not possible to go smaller than 33 with a 5x110. Praxis works did something that went down to 32, but that is only with their cranks.
46 tooth 5x110 rings are often paired with a 36 or 39 tooth inner ring (for cx). All the ones I've tried work fine with a 34 inner.
How did your experiment with the 11/40 cassette go? Is it enough or you looking for more?