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You can, but if you go by Shimano manuals you need to overcomplicate stuff with an Y cable. In that setup you need an exit to the Y. If you run both shifters to the barend and one shifter to the frame should work with less internal faffing at the cost of losing one port.
But I may be forgetting something
Not completely solid no but I assume they must have some reinforcing / internal sturcutre on high stress areas which prevents a cable being run internally from one side to the other. No need for anything to exit near the stem as long as a cable can run internally from one bar end to the other.