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@giofox
Spares availability is always an interesting point when planning big trips to remote places.. I met Ryan in Santiago 2 yeas ago as he had been waiting for 40 days for a spare 12s Sram rear derailleur (very bespoke then) to clear customs from US.
I'd go for custom wheels, triple butted spokes and double walled rims with eyelets, carry some spare spokes, if then it breaks you'll find a way to fix it. Best part of such long trips is that you have plenty of time.