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I wear over-ear headphones with glasses for flying and the seal and comfort are fine (although they are quite warm). No problems sleeping either.
Mine are Sony wh1000xm3s - I preferred them to the equivalent Bose.
I used to use in-ears but they’re not that comfy over a long period and put pressure on your ear if you sleep on them. I’d probably switch to soft earplugs if it’s a planned sleep anyway.
Dramatic_Hammer-
I have the same headphones and I used to really like them.....until the latest firmware update.
It really changed the headphones' behaviour (for the worse) and apparently it's not possible to go back to the previous firmware version. Quite disappointed in their performance now, I fly quite often and they've been a blessing until recently.
Edit; just found out they've released an new firmware update. I'll give it a go and hope for the best.
https://www.sony.co.uk/electronics/support/downloads/00016382
MementoMori
I did ponder that but I'm not sure how comfortable I'd find them after 12 hours and most of the in-ear noise cancelling ones have the boxes for battery which makes them a bit awkward to use for anything on the go.