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The answer is indeed yes and no. The problem with the first gen 5k, and the reason I’m selling mine, is you can’t connect them to egpus directly as they are tb3 only so you will not get all the performance benefits. Some apps and tasks will still use it, and I think the creative suite does alright with an eGPU these days but it’s not optimal set up wise.
@chrisbmx116 There's someone close to me selling a vega 56, a razor core x and an LG 5k screen. Is this a good setup? Would I benefit from an egpu when using photoshop / lightroom / sketch? Google tells me both yes and no...