Which way would stiffness and comfort go though? Because on the one hand, I'd expect smaller triangles to be stiffer, but then a longer seat post and a steerer with spacers probably not so much?
A smaller triangle would be stiffer laterally (everything else being equal), but longer seatposts are more compliant. So in theory the smaller bike will be both stiffer and more comfortable.
I very much doubt you (or anyone else for that matter) would notice though.
Frame bag capabilities, stiffness, comfort... you might not be able to feel the difference for the last 2 though.