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This is true.
If you have the heart and lungs of a club cyclist and you suddenly take up running you will be able to put a lot of power through your legs for a sustained period of time. But that creates a problem. The supporting muscles around your knees, ankle, calf will not be ready for it. Over use injury is likely, especially if you are older than about 25.
Muscle pain mostly, just because it's different muscles to what cycling uses I figured.