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If you haven't already I'd try all the usb ports. There's normally one that's designated as Always on which may work or be the one that doesn't work.
There may be some funky settings in the bios as well. If the same thing happens with multiple USB devices and you can't find any settings that change it I'd try a Ubuntu liveUSB and see if that has the same issue.
What laptop? Windows or Mac?
Earthing issue or some weird battery/performance management settings.