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I fell out of love with the whole USB music based thing after the Access Virus Ti. I wanted that thing to work so badly but all it did was destabilise every aspect of my music making and become a total time sink because it never worked reliably. Stand alone it was a great piece, even as a sound card it was pretty good but the USB audio integration killed the dream for me.
Having said that my mixer can send 32 tracks to usb at 96/24k. I use it with an iPad and can record 9 piece bands easily, its completely stable.
I'm very happy with the RME - it works with no fuss, the mixer matrix is excellent for home studio stuff and it sounds pretty good too. We had a Motu 828mk2 or 3, I think it was the firewire ports that were dodgy but it kept losing connection at inopportune times! Looked a lot tougher than it was.
Yeah it's a PC - think the case is about 15 years old now (maybe more!). Everything in it has been changed at least once but the problem remains... Admittedly it's inaudible at normal listening levels but it shows up on recorded inputs and layers up louder and louder that way. It isn't there with the isolated gear but it's irritating to remember to unplug stuff as USB midi and USB power is ubiquitous now.