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I've used a few different sizes in MDF and Ply and they hold up fine. That's in conjunction with the dominos which will hold well enough to trial build furniture, of course the domino kit is expensive now but mine has paid for itself over the last 10 years. I also have some jigs for drilling the Rafix, lots of expensive bits and pieces that go into making furniture which I've collected over the years. :)
There are lots of different types of connectors, I chose Rafix because they suited me. You can use the plastic blocks which screw onto the surface if it meets your criteria.
Have you given any thought to levelling the base. If you produce something with a base that sits flat on the floor you will have all kinds of problems with uneven floors. It gives you lots more to think about in terms of where the load is distributed too.