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I'd say 80% of the route has fantastic scenery and Kirkstone, Burn Edge and Whinlatter definitely doable fixed.
https://ridewithgps.com/trips/39907877
Wrynose is a pig, especially 150km into a ride.
Minibus is a great idea. I'm on said Virgin train to Kendal at the moment to do the Fred route and a man has just thrown his bike on top of mine, scratching the paintwork.