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GoatandTricycle
Will the GRX RD-RX810 work with a large cassettes at the rear and a large tooth difference at the front.
Based on the data and experience we know from ultegra, and doing the maths, that answer is no. But lets leave the "maybe" door open for now.
Looks like Shimano want you to do one or the other. Large range at the rear, or at the front, and then buy into the components that get you that. Those of us that want/need both, still have to deal with wolf dohickeys.