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mands
I wouldn't go either of those routes. A501 is really busy and traffic doesn't move much and A40 is Oxford Street which is full of buses, taxis and lemming-like pedestrians.
I'd go Wigmore Street/Mortimer St and then either Theobald's Road, Clerkenwell Rd, Old St. (Although I would look for a way round Clerkenwell Rd, it's a bit grim but no routes around spring to mind).