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The Endurace has clearance for bigger tyres. A mate is riding his in winter with studded tyres and full mudguards (with P-clips), yet it's still a proper fast road bike.
700c is just a really big wheel on a 46, and IMHO it really makes sense to go for a 650 or even a 26". I've been through the "gf bike build" (she's 5'3''), and if I were to do again I'll definitely avoid the 700 wheels.
You don't want smaller wheels on a 46?