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Yep. I'm currently planning how I can build a bike around one. Partly posted here so people buy it all before I can buy one.
Also worth noting the rim brake hub can be converted to disc.
With this:
https://www.sjscycles.co.uk/hub-spares/nuvinci-disc-brake-adapter/
But I suspect you need an expensive tool to do it:
https://www.sjscycles.co.uk/tools/nuvinci-professional-brake-adapter-tool/Not 100% clear.
Problem now would be finding a shifter at a decent price.
Mad discounts on NuVinci stuff:
https://www.bike-discount.de/en/nuvinci_cycling_enviolo