East Beers - Wednesdays - The Chesham Arms E9 6DU

If you want to only go along smaller streets from there, it gets more complicated to explain. :) I'd just do the A5204 at least to Tottenham Court Road, it's much easier, but if you don't want to, this is the best of the rest, I think:

Leave Edgware Road via Upper Berkeley Street, obviously stopping off at Green Valley for delicious provisions, and do this taxi rat-run via Portman Square and Manchester Square. That gets you to Welbeck Street, where the short contraflow to Queen Anne Street from Bentinck Street that I believe Westminster Cycling Campaign have been seeking for ages still hasn't been implemented, so you'll have to walk (it's only a short distance). At the end of the two-way section of Queen Anne Street, turn left into Mansfield Street, then right into Duchess Street, cross Portland Place, right into Hallam Street/Langham Street/Foley Street, then you'll have to walk a short stretch along Cleveland Street to Tottenham Street, right into Whitfield Street, left into the A5204 Goodge Street, then across Tottenham Court Road, right into Chenies Street, left into Ridgemount Gardens, right into Torrington Place, Byng Place, Gordon Square, Tavistock Place, etc. Across Gray's Inn Road into Ampton Street, right into Cubitt Street, right into the A201 King's Cross Road, and then left into either Lloyd Baker Street (if you like your hills a little steeper) or Margery Street (gentler). Across Amwell Street into River Street/Myddelton Square Gardens, Chadwell Street, then the little shimmy across St John Street into Owen Street. Across City Road and Goswell Road into Colebrooke Row, turn right at either Vincent Road, Noel Road, or Gerrard Road, then Danbury Road, Rheidol Terrace, Prebend Street, left along the footpath across the green by St James Church, Bishop Street, left into Basire Street, right into Popham Road, across New North Road into Ecclesbourne Road, right into Elmore Street at the end, left into Cleveland Road, right into Northchurch Road, across Southgate Road, and then Northchurch Terrace, De Beauvoir Square, St Peter's Way, and then Middleton Road all the way to London Fields. Got that? :)

(I honestly wouldn't bother if you don't know the area.)