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It depends on what aluminium the frame is made of. Each type has its own alloys and heat treatment, or temper. In my previous life as an aircraft mechanic I did lots of stuff with aluminium and somewhere in my study books I have lists of the types of alu and the treatment processes. I’m buggered if I can recall it all now, but for example the most common alu alloy is 6061 T6 It’s a 6000 series aluminium alloy, with alloys like copper, magnesium and zinc. T6 is the heat treatment. I can’t recall offhand the details of the treatment involved but it’s basically heating and then cooling at a specific rate. Ageing then completes the treatment. You can repeat the process after more welding or repairs. The point with 6061 is that is that you can re-weld it, but the whole piece needs to be heat treated again to regain full strength - a structure can lose about 45% of its strength when its heated, so it must be re-treated to T6 spec.
There are other grades of aluminium alloy which need other T heat treatments, but some of them can’t be repaired by welding again. I must dig my books out again and have a read.
Steel alloys are also heat treated, too. I remember that dear old Reynolds 531 and the later 753 were both identical in composition (manganese-molybdenum steel) but given a different temper. 753 was given a harder temper and so the tubing could be made a lot thinner than 531 and so it was lighter. It was a bastard to braze, though.
I'm still not convinced that welding on a cable guide would necessarily require a second heat treatment.