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One of my toenails has been a bit weird for a few years, but during the half marathon I did at the weekend it really, really hurt and after the race there was a lot of blood and pus (sorry to anyone reading this over breakfast) - doctor said it has multiple infections and needs to go. I've had toenails fall off before and it hasn't hurt, they just looked a bit gross.
Is that a result of running, or did you have issues with it before? I said goodbye to three toenails fairly recently. No major pain though thankfully. They just hardened up and came away.