Bigger vs smaller drivetrain combos (same gearing)

I'm going to be upgrading my fixie's drivetrain in a bit, and am currently considering my options regarding chainring / sprocket combinations. I noticed that I could have 50/18, 47/17, or 44/16 and end up with very similar ratios (2.78, 2.76, 2.75 - not necessarily going for this specifically, it's just an example). In order to decide, I'm currently aware of the following points:

• Larger components should wear out a little bit more slowly
  
• A larger chainring might not fit the frame above a certain size (but judging from a preliminary check, I should be good)
  
• A smaller chainring might give me more flexibility in terms of adjusting my gearing. I'm using the Miche system with the carrier, with 13t - 18t sprockets being available. A 50t chainring gives me ratios of 2.78 - 3.85, a 44t chainring a much more useful (to me) range of 2.44 - 3.38.
  
  

Am I missing out on some important factor / what would you guys recommend? Thanks!

EDIT: Suggested so far:

• Big is cooler
  
• Small is marginally lighter
  
• Big is marginally more efficient
  
• Whatever you have lying around / is cheaper
  
• Big might feel better?
  
  

Thanks for the help!