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That's exactly what I'm doing except no MTB wheels as I already have a real MTB. And can't afford deep wheels. Or dynamos. Or a custom Ti frame. Road/touring/whatever 700c wheel set, gravel/comfort/whatever 650b wheelset.
And both 1× and double cranksets, as I won't really need the range of 46/30 most rides
Edit: agree on 26" also. 2.25"×26" is the approx. the same wheel diameter as 700c×25mm so if you've got the clearance it won't affect geometry at all. You could have 700c×25mm, 650b×44mm and 2.25"×26" and pick and choose depending on what you're doing. Your bike is guaranteed to look stupid with at least one of those wheelsets though
y'know what if I lived in a place where there were space limitations I'd gladly go that way, two or three wheelsets and one custom Ti bike.
11-36 on all with 46-30. /csb
I wonder why 26" isnt hip yet in the same trajectory.