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It's a closed system otherwise you'll not have bite when you grab the lever.
And a small bubble should not cause the pull to be spongy. Small is however subjective. And the only reason why it's squishy is that the bubbles got into the caliper instead of being at the reservoir in the caliper. Few pumps and gentle raising the wheel then dropping it should move the bubble back up.
So yeah if you've bled it well, there shouldn't be no issue if you flip your bike upside down or hang the bike up by the rear wheel cos no bubbles...
It shouldn't matter unless you have air trapped in the brakes.