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No plumbing issues. It was borderline whether we would have enough fall for the toilet sink and shower so we had a saniflow fitted instead. Works just fine. Just don't put anything other than shit and toilet paper and wee down it and it should give years of good service. I think my house is about 4.5m wide. We don't have a wardrobe in the loft ATM but funnily enough were looking for one at IKEA the other day. We might just got for a single wardrobe or a 1.5size wardrobe. IKEA have some ok ones. Our loft has a 2.1m finished head height so don't want one that is over 1.8m tall or so.
I've got an L shaped layout 1. Works well.