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I normally use Uxbridge Road, A40, A413 for Chilterns stuff.
There's probably nicer routes slightly more north towards the canals and Harefield though you have to go through Ruislip which has its share of dickheads, but I'm normally running late so fUxbridge works. Or just bust straiht out the A40 to really save time (knocks years off your life though :)
In time to get to an Audax or some other time?
From SW15 I've always gone over Kew Bridge, Brentford High Street, Half Acre, Boston Road and then Uxbridge Road, A40, A413. That's to get there for 6am or 8am. Can imagine it might not be as nice later on in the day.