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I've tried both and prefer Blokada, it seems to block more. In theory though they're pretty similar so it may just be that I have stricter hosts files set-up. Blokada seems to persist a bit better than DNS66. It's easy enough to install and give it a test.
Worth thinking what else would stop working if you rooted. Virgin and Sky apps both refuse to work on rooted devices as does 4OD or something similar. Most banking apps also won't run.
I use DNS66 atm, have you used that and can you compare?