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at high f-numbers it's going to be harder to get things in focus
This does not make any sense.
Your 450D will stop down the aperture just before the picture is taken, so it doesn't matter if you (or the camera) sets f1.8 or f22
(we're talking about autofocus lenses, right? The finder does not get darker, as you change aperture, right?)
Does it happen across more than one lens ? Might just be the motor in one lens is busted.