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So Large is over 1000?
Which 1000 are you talking about? The trigger for enquiry is 1000ng/ml in urine, because that is the maximum elimination rate expected from somebody taking 1600μg/day spread normally throughout the day. The permitted daily dose is 1.6mg inhaled, one example of a study which found anabolic effects used 16mg orally every day for 9 weeks. The whole point of inhaling β2 agonists is that they bind to the β2 receptors in the airways and, presumably, don't fall off until they break, so the active group is not available to other systems to provide other effects even compared with alternative routes of administration of the same dose.
Because, as I said, large systemic doses are known to be performance enhancing, whereas small inhaled doses seem to have no measurable effect on athletic performance.