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The slight inconvenience, I take, is a different spoke length
For symmetrical hubs laced to asymmetrical rims, yes.
For asymmetric hubs laced to symmetrical rims, it might not even amount to that because although that can lead to a difference in spoke length from side to side, it might not if the hub designer has made the flange diameters different, and using an asymmetric rim will only yield equal length spokes if it's just the right offset and the hub wasn't already designed to use equal length spokes in a symmetrical rim.
@Heldring @frankenbike thank you for the feedback. I'm learning here.
@mdcc_tester
The slight inconvenience, I take, is a different spoke length, for an otherwise nice smooth build with same spoke length on a symmetrical rim?