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The only time I feel the Cotic is slower is on big downhills, due to being less aero, but that's probably more a function of the flared drops more than the tyres.
I'm terrified riding down big hills on narrow tyres with caliper brakes. Is it actually slower or does it just feel slower? Because I reckon for 95% of people the improved traction and lessened road buzz will mean that you're faster with big tyres.
I went from riding a Bob Jackson audax frame with 700*23c to a Cotic Escapade with 700*42c.
I think my average speed has dropped by ~0.5km/h, but comfort and enjoyment is greatly improved.
The only time I feel the Cotic is slower is on big downhills, due to being less aero, but that's probably more a function of the flared drops more than the tyres.