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Are you using the OSX drivers or the Nvidia web drivers? If the former, try the latter.
Edit: I don't think the 1080ti is natively supported so you must be using the web drivers.
The web drivers don't actually support the 1080 so apparently performance is very buggy:
http://www.nvidia.com/download/driverResults.aspx/117854/en-usYou'll probably just have to wait for Nvidia to improve the driver.
Have a MacPro at work with a 1080ti inside. Performance measured with Cinebench is below a 2014 iMac. Not so happy about this - any ideas?