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I had left hand drive for a brief period, no matter how tight I did the pedals they loosened really quickly.
Also dependant on what foot retention you are using pedals are usually designed to be flipped in one orientation - I really struggled to get my foot into my straps.
You could probably fix this by tapping a larger thread then using a helicoil or such so as the pedals can be the right way around but you'd have to sacrifice the components as they could only be used this way going forward.
Not worth the hassle for me.
Random question: got a flipflop hub and thinking of going fixed again, question is, can I get away with left-hand drive? Pedals are fine as they're super tight, question is will the lockring take the strain? Also are square taper BBs usually symmetrical, AKA will my chainline be OK? Frame's a fuji track '08.
If anyone wants reasons, I'm a lefty and enjoy confusing my friends.