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Probably. I've got TRP CX-9 mini-Vs running over 40mm GB guards and they fit ok with a few mm to spare. The BR-R353/463 brake have 90 mm arms too so work fine with the ST-5700/6700/7900 series onwards (i.e. new Super SLR brake pull). They're a little less refined in the modulation department, but plenty of power.
hamrack
veLLo
Asked this in "any question answered", but may have more expertise with the functional crowd?
Will Shimano mini brake br-r353 / 463 etc fit 45mm velo orange mudguards? And will they work with 10 speed 105 brifters?
Thanks!