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None normally. The only issue we have found is with how we have ended setting up the main tube mitring jig. For boring reasons it has to be mounted on the left of the bed with the seat stay fixture on the right (see pic) This means we can't cut the seat tube notch as the angle is too acute. I've had to hand cut and file those myself, as I don't want to be resetting Mills. However this is not practical in the long run as it requires unnecessary skilled labour, so that has lead me to.....
Good example of mitre clearance required for decent tig welding. Anything more and you'll be blowing holes in walls these thin, and even if you could bridge the gap it would build into a wonky frame.