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@gav
Just to add, some forms of doping will have benefits that stop accruing as the dose increases, there will be intrinsic barriers within the athlete. Over time some forms of doping will lose it's effect.
Epo (and blood transfusions) are the perfect drug in a way, since the performance gains will be in an essentially linear relationship to haemaglobin count, up until you get heart failure/stroke/etc. And you can turn them off and on again, want a boost, infuse blood, get your performance gain. Got a test coming up, dilute the blood or venesection.