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I have ridden my Enve 3.4's with normal tubes and clincher tyres (because tubeless tyres on a road bike is totally pointless) in the high mountains with no issue whatsoever.
Why would you choose to use inner tubes, and be subject to the issue of puncturing inner tubes, if you don't have to?
Choosing the more complex, less reliable system of the two available doesn't seem like the optimal course of action.
I have ridden my Enve 3.4's with normal tubes and clincher tyres (because tubeless tyres on a road bike is totally pointless) in the high mountains with no issue whatsoever.