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Stress isn't wacko, just weird for her.
She doesn't go well with other animals. I wouldn't mind borrowing a puppy to see if that helps, but I'm afraid that she might kill the puppy. She doesn't like other cats, dogs, tiny children (age 2 and lower) near her. Anything she might be able to kill goes down.
Arawn
Have they talked about the possibility of it being stress?
I know it sounds wacko but we had the run around for short periods over the last few years with our cat Fabric.
Fabric was periodically dragging his hind legs on the floor and also occasionally walking around with his tail puffed up and tucked between his hind legs. Fabric has a heart problem so we feared the worst, suspecting a blood clot. The first time we took him to the vet for it we all worried that he wouldn't be coming home.
After months and months of tests all physical possibilities were ruled out and it was concluded that the behaviour was entirely, er, behavioural.
A short course of kitty anti anxiety meds and he has been fine for months.
I'm sure our case was very unusual but its worth considering these things...cats are incredibly sensitive creatures even if they do hide it well most of the time. Our case was slightly confused by the fact he got a UTI, probably from the effects of stress.
We never worked out what was causing his anxiety/stress but weirdly things improved a lot once we got a puppy. Perhaps it was loneliness or boredom!