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I guess it depends how that price compares to similar sized places in the area. If the need for renovation/etc is priced in then you might not get anywhere but I don't see the harm in trying low.
Also depends how much competition there is where you're buying - our agent told us that when people see a fixer-upper they tend to go a bit mad and feel they're already getting a bargain, even if the work to bring it up to standard pushes it well over ready made equivalents.
In my recent experience of talking to estate agents:
Guide price = a range, hoping for more than lower limit but wanting to appear in more searches.
OITRO = owner wants X amount, agent doesn't expect to achieve it.