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I been using them for a long time now, mostly on roads but sometimes in towpaths and bridleways. Not a single flat, fast, comfy, wide. Very easy to mount with no tubes, hold air very well. Only downsides i can find is that they don't look the most durable tires and fairly expensive, but well worth it
Fears are unfounded, will seal many cuts and ones that are big enough to fuck the tyre badly enough to warrant putting an inner tube in would have more than likely punctured an inner tubed system anyway.
Airloss is no worse than inner tubes - I'd hazard a guess it is less bad.
Pro One's have been pretty awesome for me.