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Absolutely. You could lose 50% or more in a few days. Its about identifying the projects that are genuine and that have a lot going for them so you can have confidence that development will move in the right direction over months and years.
Just like everything else, don't invest what you can't afford to lose. Its about finding a balance of risk. You might lose your entire initial stake but you also might 10x it in three months for example.
Crown (Crown.tech) is a community run project that is building a decentralised block chain based application platform with an open API. I've been working on it since June last year.
For those of a high risk persuasion, this blockchain project is paying 30% annualized interest at the moment.
ROI has been between 70% and 30% for six months or more now.
https://stats.crowncentral.net/