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I think this is a good counterpoint to other posts - you don't always need a complete change of direction (and accompanying risk, upheaval) to make a huge difference in your life, and it's worth working out if there's a way to use existing experience in a different job in broadly the same area or industry.
Even moving to a different department may give you e.g. a line manager with a very different outlook, and gives you a good chance at dropping elements of your job which frustrate (like that tedious thing you have to do every Friday which takes much longer than anyone realises)
Sure there might be a pay or responsibility cut, but in the long term you may be building more comprehensive experience.
I have to say this thread has been amazing to read through. much positivity. such wow.
I typed out a long spiel about my current situation and then deleted it. I am financially comfortable and beginning to save for a deposit for a place after 17 years of being broke, living month to month and paying for previous bad life decisions. My job 5 months ago was stagnated after 7 years and I wasn't enjoying it. I finally got a job in the parent comp[any of the one I was in and although its still financial services I went from wealth management finance team to bank finance team. It made a big difference for me. I am mostly out of my comfort zone about 70% of the day and learning all the time. My employer is swedish and both my GF and I wanted to move there even before my old company were bought out. So plans are afoot and things are moving.
Switching to a new department/area within the same company has given me a big kick of enthusiasm for what I do.
@Invent have you considered staying in the medical profession but switching to something like training? training the next generation? or even just getting into medical education as a whole? It could still provide the helping others part but with generally less life and death stress. this is my partners field and she comes home excited every day babbling about this stuff all the time.