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Yes, that would make sense.
I've gone back to tubes for IndyPac as I'm using my best wheels. They're a bit old now so I don't mind if they take a bit of wear. Now I've discovered 9/10 sp wheels take 11 sp MTB cassettes they have a second career ahead of them!
The Di2 is worthwhile for the multiple shift positions; wouldn't be such a big deal purely for smoother shifting.
frank9755-
I yeah I ignored that and it's easier for travel. But with the reduced shifting I could manage with a single shifter. I did many thousands of km on my TT bike with only extension shifters. Not optimal but certainly manageable. On really long rides I'd get a bit of wrist ache but that was probably just as much due to the bend than the shifting. Never a big deal, not like some people finishing TABR with full on carpal tunnel and similar nerve injuries.
hippy
I'm sticking with discs, Di2, dyno hubs and tubes.
If I was racing Indipac though I'd probably just take my S-Works. You won't need brakes for about 4000 of the 5000k and with the reduced gear changing compared to TCR, cables are one less thing to drain batteries. Less likely to get overuse injuries in hands with cable stuff too so I'd go for my lighter bike and older Dura Ace config.