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I think the rule of thumb for driveline efficiency these days is: big chainring - everything except biggest two sprockets.
Or you can read about testing this in detail: http://www.bikeradar.com/us/road/gear/article/friction-facts-free-speed-from-proper-shifting-44016/
hippy
Scilly.Suffolk
Cross-chaining stopped being a thing with, I think, 9 speed. Certainly 10/11.
Which isn't to say there isn't a more efficient chainring/sprocket combination.
But it will no longer lead to an early death.