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The Campagnolo Ergopower hood shape felt much more natural to wrap my hand round them, the latest one with the smaller downshift button were extremely comfortable;
For some reason I found the 105 5800 (et all) hood surprisingly uncomfortable except for the Di2 one.
The older shape were comfortable enough (especially as a singlespeed levers) but the downshift button although great to shift a whole gear in one stroke, felt like it's on the way, and the gear cable routing made the transition from hood to bar a bit awkward;
@edscoble What's the main motivation for campag over Shimano, hood shape?