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I was just sort of going off the top of my head. My thinking was to get you off the main roads because there are shitloads of lights along the direct route, plus loads of pollution on the busiest roads. Mildly revised version here
My thinking is that north of the A40 is less busy than South. Going Soho way and the peds and lights I thought would be extra slow. It is a little pick-your-poison, fast and hellish or slow and stopy-starty. I'd maybe give both a go and see what you think as it might be that most recent one you posted is nicer than it seems - hard to tell without actually riding it!
Cheers - I was looking at routes in that kind of way - any reason I should avoid switching it to a more direct route like this?