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Rodolfo
Bigger is smoother.
I usually use this calculator to check chain length vs. chainstay length, but it seems to be offline at the moment. This one is a bit more useful as it shows a table of potentially magic gears for any given chainstay length.
50/18 isn't most people's idea of spinny, and it's much higher than 39/16. There's not much evidence that spinny is better for your knees than mashing, if anything the evidence seems to point the other way. Nonetheless, if you want to spin without buying any new sprockets, 39/16 is a decent everyday gear.