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As @edscoble says it is down to frame material, carbon vs alu.
I found this comparison article to be very informative (SuperSix EVO Hi-MOD vs. CAAD12)
https://cyclingtips.com/2017/01/cannondale-caad12-vs-supersix-evo-hi-mod-road-disc-bike-comparison-review/I had been lusting after a SuperSix but after reading the above think my next bike/frame will be a CAAD12
EstelleGetty
swedeee
Between a Supersix EVO 105 and a CAAD12 105 where is the difference?