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In the last 4 years or so I've not ridden anything with more than 25s so it's not a huge issue.
Thanks @edscoble but I don't want a pinnacle or a Saracen
I'd not risk larger than 28 in the CAAD12, although mine come up at around 30 on the wheels I use.
Anyway, I'd not go larger as the clearances (under the fork, particularly) just isn't there.